Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 1995, Vol. 6 ›› Issue (3): 146

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PREPARATION OF BONE TUMOR THERAPEUTIC RADIOPHARMACEUTICALS 153Sm-EDTMP

Luo Shunzhong (罗顺忠)1, Pu Manfei (蒲满飞)1, Qiao Jian (谯健)1, Liu Zhonglin (刘中林)1, Zhao Pengji (赵鹏骥)1, Fu Yibei (傅依备)1, Deng Houfu (邓侯富)2   

  1. 1 Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Chengdu 610003;
    2 West China University of Medical Science, Chengdu 610041
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Luo Shunzhong (罗顺忠), Pu Manfei (蒲满飞), Qiao Jian (谯健), Liu Zhonglin (刘中林), Zhao Pengji (赵鹏骥), Fu Yibei (傅依备), Deng Houfu (邓侯富). PREPARATION OF BONE TUMOR THERAPEUTIC RADIOPHARMACEUTICALS 153Sm-EDTMP.Nuclear Science and Techniques, 1995, 6(3): 146

Abstract: Samarium-153-EDTMP (ethylene diamine tetramethylene phosphonate), for its promising biological properties, has been proved as a palliating therapeutic agent for bone tumor in human beings. 1153Sm with high radionuclear purity and specific activity of 5.18 GBq (140 mCi)/mg Sm2O3 was prepared by irradiating natural Sm2O3(153Sm, 26.7%) sample, replacing costly enriched samarium oxide target, at a flux of 4x1013n-cm-2-s-1 for 110h. The yield of 153Sm complexing with EDTMP is greater than 98% at pH 8-10 in boiling water bath for 30 min, and not significantly decreases within one week after 153Sm-EDTMP complex formation.

Key words: Bone tumor, Therapeutic radiopharmaceuticals, 153Sm, 153Sm-EDTMP