Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2002, Vol. 13 ›› Issue (2): 105

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Preparation and characteristics of 117mSn-HEDTMP

HE Jia-Heng, LUO Shun-Zhong, YANG Yu-Qing, PU Man-Fei, WANG Guan-Quan, Bing Wen-Zheng   

  1. Institute of Nuclear Physics and Chemistry, China Academy of Engineering Phusics. Mianyang 621900
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HE Jia-Heng, LUO Shun-Zhong, YANG Yu-Qing, PU Man-Fei, WANG Guan-Quan, Bing Wen-Zheng. Preparation and characteristics of 117mSn-HEDTMP.Nuclear Science and Techniques, 2002, 13(2): 105

Abstract: Tin-117m(t1/2 14d; γ 150keV, 86%) is an ideal tracer for studying biological behavior of tin compounds as well as for developing clinically-useful radiopharmaceuticals. It had been reported that Sn-117m(4+] DTPA has unexpectedly high bone uptake and bone-to-blood ratio, and is potentially useful as an agent for skeletal scintigraphy and radiotherapy of bone tumors. In this work, HEDTMP [N-(2hydroxyethyl) ethlenediamine-1,1,2-tri (methylene phosphonic acid)] was synthesized. Let it form complex with 117mSn. The formation conditions, stability and distribution coefficient between oil and water of the complex were investigated.

Key words: 117mSn, HEDTMP, Bone tumor