Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2002, Vol. 13 ›› Issue (2): 65

    Next Articles

Study of three-dimensional PET and MR image registration based on higher—order mutual information

REN Hai-Ping1, YANG Hu2, CHEN Sheng-Zu1, WU Wen-Kai1   

  1. 1 Department of Nuclear Medicine, Cancer Hospital, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100021;
    2 Department of Biomedical Engineering, Capital University of Medical Sciences, Beijing 100054
PDF ShareIt Export Citation
REN Hai-Ping, YANG Hu, CHEN Sheng-Zu, WU Wen-Kai. Study of three-dimensional PET and MR image registration based on higher—order mutual information.Nuclear Science and Techniques, 2002, 13(2): 65

Abstract: Mutual information has currently been one of the most intensively researched measures. It has been proven to be accurate and effective registration measure. Despite the general promising results, mutual information sometimes might lead to misregistration because of neglecting spatial information and treating intensity variations with undue sensitivity. In this paper, an extension of mutual information framework was proposed in which higher-order spatial information regarding image structures was incorporated into the registration processing of PET and MR. The second-order estimate of mutual information algorithm was applied to the registration of seven patients. Evaluation from Vanderbilt University and our visual inspection showed that sub-voxel accuracy and robust results were achieved in all eases with second-order mutual information as the similarity measure and with Powell's mmltidimensional direction set method as optimization strategy.

Key words: Higher-order mutual information, Multi-modality medical image, Registration