Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2007, Vol. 18 ›› Issue (3): 159 doi: 10.1016/S1001-8042(07)60039-6

• RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICIN • Previous Articles     Next Articles

Preparation and biological evaluation of 99Tcm-labelled fatty acids

LIANG Jixin HU Ji* CHEN Baojun LUO Lianzhe LI Hongyu SHEN Langtao LUO Zhifu   

  1. Isotope Department, China Institute of Atomic Energy, Beijing 102413, China
LIANG Jixin HU Ji CHEN Baojun LUO Lianzhe LI Hongyu SHEN Langtao LUO Zhifu. Preparation and biological evaluation of 99Tcm-labelled fatty acids.Nuclear Science and Techniques, 2007, 18(3): 159     doi: 10.1016/S1001-8042(07)60039-6
Citations
Altmetrics

Abstract: The aim of the present work was to develop radiolabelling fatty acids based on 99Tcm carbonyl chemistry for heart imaging. Undecanoic acids functionalised with iminodiacetatic acid and cysteine were radiolabelled with [99Tcm (CO)3(H2O)3]+ intermediates, and their radiolabelling conditions were carefully studied. Biodistribution of 99Tcm (CO)3-CYST FAC11 and 99Tcm (CO)3-IDA FAC11 were observed in normal mice. The results showed that two 99Tcm-labelled compounds had similar profile in terms of high initial radioactivity uptake and rapid washout of radiotracers in the heart. 99Tcm (CO)3-IDA FAC11 was mainly excreted via hepatobiliary system in contrast to 99Tcm (CO)3-CYST FAC11, which was excreted from urinary system. It may be in part attributed to the more lipophilicity of 99Tcm (CO)3-IDA FAC11 than 99Tcm (CO)3-CYST FAC11.

Key words: 99Tcm-labelling, Fatty acid derivatives, Biodistribution