Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2019, Vol. 30 ›› Issue (11): 164 doi: 10.1007/s41365-019-0682-3

• ACCELERATOR, RAY AND APPLICATIONS • Previous Articles     Next Articles

Monte Carlo assessment of coded aperture tool for breast imaging: a Mura-mask case study

O. Kadri1,2 • A. Alfuraih1   

  1. 1 Department of Radiological Sciences, College of Applied Medical Sciences, King Saud University, PO Box 10219, Riyadh 11433, Saudi Arabia
    2 National Center for Nuclear Sciences and Technologies, 2020 Tunis, Tunisia
  • Received:2019-04-19 Revised:2019-06-21 Accepted:2019-06-26
  • Contact: O. Kadri E-mail:okadri@cern.ch
  • Supported by:
    This work was supported by The National Plan for Science, Technology and Innovation (MAARIFAH), King Abdulaziz City for Science and Technology, Kingdom of Saudi Arabia, Award Number (12-MED2516-02).
PDF ShareIt Export Citation
O. Kadri, A. Alfuraih. Monte Carlo assessment of coded aperture tool for breast imaging: a Mura-mask case study.Nuclear Science and Techniques, 2019, 30(11): 164     doi: 10.1007/s41365-019-0682-3

Abstract: The main purpose of this work was to perform a rigorous computational study on scintimammography with a Mura-mask based on Monte Carlo simulation of voxelized breast phantoms. Three main objectives were addressed: (1) verification of Geant4 version 10.4, (2) optimization of the imaging setup, and (3) small tumor detection and localization. We successfully verified the Geant4-based imaging of a commonly used phantom in the field. We used a Mura-mask with a 41×41 array pattern with adjustable thickness, material, and hole shape (box and cylinder); a low-energy high-resolution collimator with different hole shapes (cylinder and hexagon); and a voxelized breast phantom with different sizes (small, medium, and large) and glandularity percentages (low, medium, and high). We also compared the detector crystal outputs of CdZnTe and NaI(Tl). The simulation was followed by a deconvolution procedure, and the data (images) were statistically emphasized. Statistical metrics indicate that the Mura-mask (W material with 1.5 mm thickness and box holes) combined with a CdZnTe detector leads to the optimum point spread function. Finally, a preliminary study on small-sized tumor detection and localization was conducted with different tumor-to-background ratios (from 2 to 12). Tumors with diameters of 5 and 8 mm could be detected, while those of 2 mm were undetectable. Nevertheless, this study enhances our understanding of the early detection of tumors in the field of scintimammography.

Key words: Geant4, Voxelized breast phantom, Scintimammography, Mura-mask