18F-PBR06 PET/CT imaging of inflammation and differentiation of lung cancer in mice

doi:10.1007/s41365-019-0597-z

Nuclear Science and Techniques ›› 2019, Vol. 30 ›› Issue (5): 83 doi: 10.1007/s41365-019-0597-z

• NUCLEAR CHEMISTRY,RADIOCHEMISTRY,RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE • Previous Articles Next Articles

¹⁸F-PBR06 PET/CT imaging of inflammation and differentiation of lung cancer in mice

He Zhang ^1,2,3, Hui Tan ^1,2,3, Wu-Jian Mao ^1,2,3, Jun Zhou ^1,2,3, Zhe-Quan Fu ^1,2,3, Yan Hu ^1,2,3, Jie Xiao ^1,2,3, Qing-Yu Lin ^1,2,3, Hong-Cheng Shi ^1,2,3, Deng-Feng Cheng ^1,2,3

^1. Shanghai Institute of Medical Imaging, Shanghai 200032, China
^2. Department of Nuclear Medicine, Zhongshan Hospital, Fudan University, Shanghai 200032, China
^3. Institute of Nuclear Medicine, Fudan University, Shanghai 200032, China

Received:2018-10-21 Revised:2018-11-08 Accepted:2018-11-09
Contact: Deng-Feng Cheng E-mail:cheng.dengfeng@zs-hospital.sh.cn
Supported by:
This work was funded in part by the National Natural Science Foundation of China (Nos. 11875114, 81471706, and 81871407), Science and Technology Commission of Shanghai Municipality (No. 16410722700), and sponsored by the Shanghai Sailing Program (No. 17YF1417400).

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He Zhang, Hui Tan, Wu-Jian Mao, Jun Zhou, Zhe-Quan Fu, Yan Hu, Jie Xiao, Qing-Yu Lin, Hong-Cheng Shi, Deng-Feng Cheng. ¹⁸F-PBR06 PET/CT imaging of inflammation and differentiation of lung cancer in mice.Nuclear Science and Techniques, 2019, 30(5): 83 doi: 10.1007/s41365-019-0597-z

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Abstract

Abstract: The present study explored the 18-kDa translocator protein radioligand ¹⁸F-PBR06 as a PET imaging biomarker for diagnosis of inflammation and compared it with ¹⁸F-FDG for differentiation of inflammation and lung tumors in animals. ¹⁸F-PBR06 was synthesized with an average decay-corrected radiochemical yield of 30–40% (end of synthesis, EOS), and the radiochemical purity was greater than 99%. The inflammation-to-blood ratio of ¹⁸F-PBR06 (3.53 ± 0.26) was higher than the tumor-to-blood ratio (1.77 ± 0.35) (P < 0.001). The inflammation-to-muscle ratio of ¹⁸F-PBR06 (2.33 ± 0.64) was also higher than the tumor-to-muscle ratio (1.45 ± 0.14) (P = 0.036). Micro-PET/CT images showed high uptake of ¹⁸F-FDG in both inflamed muscles and lung tumor tissues. However, ¹⁸F-PBR06 uptake in inflamed muscles remained higher than that in the lung tumor tissues, following 90 min of dynamic Micro-PET/CT imaging. Further, macrophages in the inflammatory regions showed a higher fluorescence signal than in lung tumor tissues. Results of the study confirmed that ¹⁸F-PBR06 PET/CT imaging allowed for diagnosis of inflammation. Moreover, ¹⁸F-PBR06 uptake in the inflammatory regions was significantly higher than in lung tumor tissues, suggesting that ¹⁸F-PBR06 PET/CT imaging has potential to differentiate between peripheral lung cancer and inflammation nodules.

Key words: TSPO, Macrophage, PET/CT, Inflammation, Lung cancer

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¹⁸F-PBR06 PET/CT imaging of inflammation and differentiation of lung cancer in mice

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