Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2014, Vol. 25 ›› Issue (6): 060302 doi: 10.13538/j.1001-8042/nst.25.060302

• NUCLEAR CHEMISTRY,RADIOCHEMISTRY,RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE • Previous Articles     Next Articles

Preparation of 188Re-HEDP lyophilized kit for instant bone metastases therapy

YANG Zhi1,ZHU Hua1,LI Nan1,MA Yun-Xia1,ZHANG Yan1   

  1. 1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education),
    Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China
  • Contact: YANG Zhi E-mail:pekyz@163.com
  • Supported by:

    Supported by the National Natural Science Foundation of China(Nos. 81071198, 81172083 and 81371592) and Beijing Natural Science Foundation (No. 7132040)

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YANG Zhi, ZHU Hua, LI Nan, MA Yun-Xia, ZHANG Yan. Preparation of 188Re-HEDP lyophilized kit for instant bone metastases therapy.Nuclear Science and Techniques, 2014, 25(6): 060302     doi: 10.13538/j.1001-8042/nst.25.060302

Abstract:

Hydroxyethylidene diphosphonate (HEDP) was prepared and labeled with rhenium-188. Its lyophilized kit
was developed for instant preparing of 188Re-HEDP. 188Re-HEDP showed high focile uptake in normal mice
(> 30% ID/g at carrier co-injection) in BABLC/SPF mice. High quality single photon emission computed
tomography (SPECT) image of New Zealand rabbit was obtained at 4 h after intravenous injection of 74MBq
radiotracer. The lyophilized HEDP kit affords the new opportunity for routine clinical application in bone
metastases therapy.

Key words: Rhenium-188, Hydroxyethylidene diphosphonate, Lyophilized kit, Bone tumor therapy