Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2015, Vol. 26 ›› Issue (4): 040302 doi: 10.13538/j.1001-8042/nst.26.040302

• NUCLEAR CHEMISTRY,RADIOCHEMISTRY,RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE • Previous Articles     Next Articles

Efficient removal of uranium from mice by a novel compound of fullerence multi-macrocyclic polyamine derivatives

LIU Xiao-Qing, 1,2YANG Yuan-You,1,2 LIAO Jia-Li, 1,2OU Wei,1,2 KONG Fang,1,2 LAN Jing-Bo,3 LUO Shun-Zhong,4 LIU Guo-Ping,4 HE Jia-Heng, 4YANG Ji-Jun, 1,2TANG Jun,1,2 LIU Ning1,2   

  1. 1Key Laboratory of Radiation Physics and Technology, Sichuan University, Chengdu 610064, China
    2Institute of Nuclear Science and Technology, Sichuan University, Chengdu 610064, China
    3College of Chemistry, Sichuan University, Chengdu 610064, China
    4Institute of Nuclear Physics and Chemistry, CAEP, Mianyang 621900, China
  • Contact: LIAO Jia-Li; LIU Ning E-mail:liaojiali@scu.edu.cn; nliu720@scu.edu.cn
  • Supported by:

    Supported by National Natural Science Foundation (Nos. 21071102, 91126013 and 21371124), Joint Funds of China National Natural Science Foundation and China Academy of Engineering Physics (No. U1330125) and National Fund of China for Fostering Talents in Basic Science (No. J1210004)

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LIU Xiao-Qing, YANG Yuan-You, LIAO Jia-Li, OU Wei, KONG Fang, LAN Jing-Bo, LUO Shun-Zhong, LIU Guo-Ping, HE Jia-Heng, YANG Ji-Jun, TANG Jun, LIU Ning. Efficient removal of uranium from mice by a novel compound of fullerence multi-macrocyclic polyamine derivatives.Nuclear Science and Techniques, 2015, 26(4): 040302     doi: 10.13538/j.1001-8042/nst.26.040302

Abstract:

Uranium removal efficacy of fullerence multi-macrocyclic polyamine derivatives (C60-MMP), a novel chelating agent, was evaluated in mice. C60-MMP was administrated intravenously into mice at 30 min after the uranium contamination. The molar ratio of chelating ligand/uranium was about 1 : 1. The results indicate that C60-MMP can effectively prevent accumulation of uranium in liver at 8 h after C60-MMP injection. At 48 h after the last injection, uranium deposition in liver of C60-MMP treated mice is approximately 65% less than that of the control group. C60-MMP reacted positively in promoting the removal of uranium from kidney, and the urinary uranium excretion increased significantly, compared with the control and DTPA-treated mice. However, repeated administration of C60-MMP, and combined injection of DTPA and C60-MMP, did not show desirable effects on uranium removal from mice. It implies that more investigations are needed for the treatment protocols and clinical applications of C60-MMP.

Key words: Uranium, Internal contamination, Removal, Fullerence multi-macrocyclic polyamine derivatives (C60-MMP)