Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2017, Vol. 28 ›› Issue (5): 72 doi: 10.1007/s41365-017-0225-8


Biological effects of human lung cells MRC-5 in CBCT positioning for image-guided radiotherapy

Chu-Feng Jin1,2*, Hui Liu2, Wen-Yi Li2, Rui-Fen Cao2   

  1. 1 School of Nuclear Science and Technology, University of Science and Technology of China, Hefei 30027, China
    2 Key Laboratory of Neutronics and Radiation Safety, Institute of Nuclear Energy Safety Technology, Chinese Academy of Sciences, Hefei 230031, China
  • Supported by:

    Supported by the Strategic Priority Research Program of Chinese Academy of Sciences (No. XDA03040000), the National Natural Science Foundation under Grant No. 30900386, the Anhui Provincial Natural Science Foundation under Grant Nos. 090413095 and 11040606Q55, and the National Natural Science Foundation of
    Department of Education of Anhui Province under Grant No KJ2010B380.

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Chu-Feng Jin, Hui Liu, Wen-Yi Li, Rui-Fen Cao. Biological effects of human lung cells MRC-5 in CBCT positioning for image-guided radiotherapy.Nuclear Science and Techniques, 2017, 28(5): 72     doi: 10.1007/s41365-017-0225-8


Image-guided radiotherapy (IGRT) provides precise positioning for the tumor target, but it may bring extra irradiation dose in the target positioning with a cone
beam CT (CBCT) which has been increasingly used in IGRT. In this work, we focused on biological effects of the low-dose irradiation in IGRT, which have not been considered so far. Primary human fibroblasts cells from the lung and MRC-5 were irradiated by a CBCT. DNA doublestrand breaks (γ-H2AX foci) and micronucleus frequency of the irradiated samples were analyzed. Compared to the control, the γ-H2AX foci yields of the samples irradiated to 16 mGy increased significantly, and the micronuclei rate of the samples irradiated for 3 days increased notably. The dose by imaging guidance device can be genotoxic to normal tissue cells, suggesting a potential risk of a secondary cancer. The effects, if confirmed by clinical studies, should be considered prudentially in designing IGRT treatment plans for the radiosensitive population, especially for children.

Key words: Image-guided radiotherapy, Cone beam CT, Imaging irradiation, Biological effects, Secondary cancer