Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2009, Vol. 20 ›› Issue (1): 17-21 doi: 10.13538/j.1001-8042/nst.20.17-21

• RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICIN • Previous Articles     Next Articles

Comparison of diagnostic accuracy between 18F-FDG PET and PET/CT for pulmonary neoplasm

CHEN Yangchun1 CHEN Ping1,* TIAN Jiahe2 CAI Xin1 YE Guangchun1 DENG Huaifu1 YANG Xiaofeng3   

  1. 1 Department of PET/CT Center, No.1 Hospital Affiliated to Guangzhou Medical College, Guangzhou 510230, China 2 Department of Nuclear Medicine, The Chinese PLA General Hospital, Beijing 100853, China 3 Department of Nuclear Medicine, The People’s Hospital of Xinjiang Uygur Autonomous Region, Urumuqi 830001, China
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CHEN Yangchun, CHEN Ping, TIAN Jiahe, CAI Xin. Comparison of diagnostic accuracy between 18F-FDG PET and PET/CT for pulmonary neoplasm.Nuclear Science and Techniques, 2009, 20(1): 17-21     doi: 10.13538/j.1001-8042/nst.20.17-21

Abstract:

Aimed at comparing diagnostic accuracy of 18F-FDG PET with PET/CT for pulmonary neoplasm, a study based on multi-center clinical trial of the diagnoses, in randomized and semi-blind ways, was executed from January 2006 to June 2007. It included 55 patients, i.e. 16 with histopathologically proved lung tumors, 16 with tuberculosis and 23 with benign lesions (inflammation, pseudotumor, granuloma, fibrosis and others). The histopathologic and clinic results were served as reference standard. Statistical significances in pulmonary nodule diagnosis between 18F-FDG PET and PET/CT were determined with 95% confidence interval obtained by ROC analysis. The 18F-FDG PET detected lung neoplasm with a sensitivity of 87.5% (14/16), a specificity of 59.0% (23/39), an accuracy of 67.3% (37/55) and a positive-likelihood ratio of 2.13. The 18F-FDG PET/CT detected lung neoplasm with a sensitivity of 93.8% (15/16), a specificity of 61.5% (24/39), an accuracy of 70.9% (39/55) and a positive-likelihood ratio of 2.43. The area under curves (AUC) of 18F-FDG PET and PET/CT were 0.803±0.068 and 0.799±0.063, respectively. It can be concluded that the diagnostic accuracy for malignant pulmonary nodules between 18F-FDG PET and PET/CT was not statistically different.

Key words: 18 F-FDG, PET/CT, Pulmonary neoplasm, Receiver operating characteristic