Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2009, Vol. 20 ›› Issue (6): 325-330 doi: 10.13538/j.1001-8042/nst.20.325-330


Potential application of SSRF in radiation oncology: The aspects of radiobiology

FU Shen1 JIANG Guoliang2,*   

  1. 1 Shanghai No.6 People’s Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China
    2 Shanghai Cancer Hospital of Fudan University, Shanghai 200032, China
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FU Shen, JIANG Guoliang. Potential application of SSRF in radiation oncology: The aspects of radiobiology.Nuclear Science and Techniques, 2009, 20(6): 325-330     doi: 10.13538/j.1001-8042/nst.20.325-330


Conventional radiotherapy remains to be one of the most useful treatments for cancer, but it is not the best strategy to maximize the effects on the tumors and minimize the damage to the surrounding tissues because of its physical and radiobiological characteristics. Synchrotrons represent a unique method for an innovative anti-cancer treatment due to the physical features (i.e. high fluence, tunable and collimated) of X-ray induced by synchrotron, so photon activation therapy and microbeam radiation treatment have been developed, but it is very imperative to understand the radiobiological mechanism of synchrotron radiation before we could transfer the strategy into the clinic. This paper is to summary the results of in vitro and in vivo experiments with synchrotron radiation, and review the advances of molecular and cellular radiobiological mechanism involved in synchrotron radiation. Since Shanghai Synchrotron Radiation Facility (SSRF) has produced the first synchrotron, it will provide the unique opportunity for the study of radiobiological effects of synchrotron radiation.

Key words: Synchrotron radiation, Radiobiology, Photoactivated radiotherapy, Microbeam radiation therapy