Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2018, Vol. 29 ›› Issue (4): 56 doi: 10.1007/s41365-018-0387-z


Methodological study on endogenous calcium absorptivity using rats and 41Ca tracing

Hui Zhang 1,2 • Liang Dou 1 • Xiao-Ming Wang 1 • Sheng-Quan Mi 3 • Qing-Zhang Zhao 1 • Shan Jiang 1 • Ming He 1   

  1. 1 China Institute of Atomic Energy, Beijing 102413, China
    2 Technical Physics Institute of Heilongjiang Academy of Sciences, Harbin 150086, China
    3 Department of Biology, College of Applied Arts and Sciences, Beijing Union University, Beijing 100083, China
  • Contact: Ming He
  • Supported by:

    This work was supported by the National Nature Science Foundation of China (No. 11375272).

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Hui Zhang, Liang Dou, Xiao-Ming Wang, Sheng-Quan Mi, Qing-Zhang Zhao, Shan Jiang, Ming He. Methodological study on endogenous calcium absorptivity using rats and 41Ca tracing.Nuclear Science and Techniques, 2018, 29(4): 56     doi: 10.1007/s41365-018-0387-z


Elemental calcium plays an important role in human physiology. In order to study the relationship between Ca-intake, Ca-chemical formulation, and Ca-absorptivity, a balance experiment using a 41Ca tracer technique in SD rats was conducted to measure the endogenous fecal calcium and true absorption of calcium. Apparent absorption of calcium was measured as a control to the endogenous calcium labeling experiment. These results show that by using 41Ca labeled endogenous calcium in vivo, researchers could obtain the true calcium absorption data without extrinsic labeling. Therefore, the method was not affected by the chemical structure or type of calcium supplement and might be used in evaluating the absorptivity of marketed calcium supplements.

Key words: Endogenous calcium absorptivity, 41Ca tracer, Accelerator mass spectrometry measurement