Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2018 Impact factor 0.961

Nuclear Science and Techniques ›› 2013, Vol. 24 ›› Issue (S1): S010312

• NUCLEAR CHEMISTRY,RADIOCHEMISTRY,RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE • Previous Articles     Next Articles

Pulse radiolysis and laser flash photolysis study of balofloxacin

XU Yulie1,2 LIU Yancheng1,2 LI Haixia1,2 ZHANG Peng1 TANG Ruizhi1,2 CAO Xiyan3 WANG Wenfeng1,*   

  1. 1Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China 2Graduate University of Chinese Academy of Science, Beijing 100049, China 3School of Chemistry and Chemical Engineering, Hunan University of Science and Technology, Xiangtan 411201, China
  • Contact: WANG Wenfeng E-mail:wangwenfeng@sianp.ac.cn
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XU Yulie, LIU Yancheng, LI Haixia, ZHANG Peng, TANG Ruizhi. Pulse radiolysis and laser flash photolysis study of balofloxacin.Nuclear Science and Techniques, 2013, 24(S1): S010312

Abstract:

Pulse radiolysis studies of the reactions between balofloxacin (BFX) and eaq ? , hydroxyl radical (˙OH), and N3 · were carried out to investigate the photosensitive toxicity of BFX. The BFX radical anion formed in the reaction of BFX with eaq ? was located at 380 nm. The transient species formed in the reaction of BFX with ˙OH radical were located in the region of 370 nm to 580 nm, with a maximum λmax at 390 nm. The BFX radical cation was obtained by reacting BFX with N3˙, and showed an absorption band at around 365 nm. The UV-Vis absorption of the BFX was found to be clearly dependent on pH. The pKa value of BFX was estimated to be 6.0±0.2. Under neutral conditions, the rate constants of BFX reacting with N3˙ and eaq ? were determined to be 1.3×1010 dm3·mol?1·s?1 and 1.4×1010 dm3·mol?1·s?1, respectively.