Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2005, Vol. 16 ›› Issue (5): 289

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Synthesis and biodistribution of [131I]IMPY

LU Chun-Xiong, WU Chun-Ying, JIANG Quan-Fu   

  1. Jiangsu Institute of Nuclear Medicine, Wuxi 214063
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LU Chun-Xiong, WU Chun-Ying, JIANG Quan-Fu. Synthesis and biodistribution of [131I]IMPY.Nuclear Science and Techniques, 2005, 16(5): 289

Abstract: The synthesis and biodistribution of β-amyloid plaques imaging agent [131I]-2- (4′-dimethylaminophenyl)- 6-iodoimidazo[1,2-α] pyridine ([131I]IMPY) were reported. The chemical structure of the labeling precursor 2-(4′-dimethylaminophenyl)-6-(tributylstannyl)imidazo[1,2-α] pyridine and all its intermediates were verified by IR,HNMR and MS. The radioiodinated compound was prepared using iododestannylation reaction by hydrogen peroxide. Final radiochemical purity was above 95% determined by TLC. The in vivo biodistribution of [131I]IMPY in normal mice showed excellent brain uptake and washout, indicating this thioflavin-T based small molecular probe has potential for in vivo imaging amyloid deposits.

Key words: β-amyloid plaques, [131I]IMPY, Synthesis