Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2003, Vol. 14 ›› Issue (2): 135

• RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICIN • Previous Articles     Next Articles

Kinetic study on ligand-exchange reaction between ethylenedicysteine (EC) and 99mTc-glucoheptonate (99mTc-GH)

ZHU Jun-Qing, WU Chun-Ying, LU Chun-Xiong   

  1. State Key Laboratory of Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063
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ZHU Jun-Qing, WU Chun-Ying, LU Chun-Xiong. Kinetic study on ligand-exchange reaction between ethylenedicysteine (EC) and 99mTc-glucoheptonate (99mTc-GH).Nuclear Science and Techniques, 2003, 14(2): 135

Abstract: A detailed kinetic study of ligand-exchange reaction between 99mTc-GH and EC was carried out. The rate constants (k) of ligand-exchange reaction at different EC concentrations and different pH values were calculated. The k values (L·mol-1·min-1) were 3.7×103, 4.1×103, 3.9×103 and 3.9×103 at EC concentrations (μmol·L-1) of 559.7, 279.9, 186.6 and 55.97, respectively, while k values were 3.7×103, 3.4×103, 1.9×103 and 3.1×102 when pH values were 10, 9, 8 and 7, respectively, and k had an increase of the order of magnitude from pH 7 to pH 8. It demonstrated that k of the ligand exchange reaction was pH dependent and pH value of the reaction solution must be equal to or little higher than 8 in order to make the labeling yield of 99mTc-EC higher than 90%.

Key words: 99mTc-EC, Ligand exchange reaction kinetics, Rate constant