Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2003, Vol. 14 ›› Issue (2): 131

• RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICIN • Previous Articles     Next Articles

A study on indirect radiolabeling of IgG with carrier free 188Re

ZHANG Xiu-Li, WANG Yong-Xian, LI Jun-Ling, YIN Duan-Zhi   

  1. Shanghai Institute of Nuclear Research, the Chinese Academy of Sciences, Shanghai 201800
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ZHANG Xiu-Li, WANG Yong-Xian, LI Jun-Ling, YIN Duan-Zhi. A study on indirect radiolabeling of IgG with carrier free 188Re.Nuclear Science and Techniques, 2003, 14(2): 131

Abstract: 188Re labeled monoclonal antibodies are potential candidates for use in radioimmunotherapy. S-Bz-MAG3 as a bifunctional chelating agent was used for labeling of IgG with carrier free 188Re by pre-radiolabeling of the chelating approach. The conjugation conditions were optimized. The stability of 188Re-MAG3-IgG in vitro was high. The results may be useful to the studies of 188Re labeled MAbs for radioimmunotherapy.

Key words: Carrier free 188Re, IgG, S-Bz-MAG3, Radioimmunotherapy, Bifunctional chelating agent, Indirect radiolabeling