Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2003, Vol. 14 ›› Issue (2): 127

• RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICIN • Previous Articles     Next Articles

In-vivo behavior of tin-radiopharmaceuticals

HE Jia-Heng, LUO Shun-Zhong, WANG Guan-Quan, YANG Yu-Qing, PU Man-Fei, LIU Guo-Ping   

  1. Institute of Nuclear Physics and Chemistry, the Chinese Academy of Engineering Physics, Mianyang 621900
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HE Jia-Heng, LUO Shun-Zhong, WANG Guan-Quan, YANG Yu-Qing, PU Man-Fei, LIU Guo-Ping. In-vivo behavior of tin-radiopharmaceuticals.Nuclear Science and Techniques, 2003, 14(2): 127

Abstract: Tin is an essential ingredient of most technetium-99m radiopharmaceuticals but its in-vivo distribution and long-term fate are not well understood. This work describes distribution in mice of several tin-117m labeled compounds. The results indicate that stannic-HEDTMP appears to be the best overall bone localizing agent with very low blood, muscle, kidney, or liver uptake, and its binding to bone is higher than that of tin-117m-DTPA, which make it potentially useful as an agent for skeletal scintigraphy and radiotherapy of bone tumors.