Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2003, Vol. 14 ›› Issue (2): 123


Preparation and bio-distribution of bone tumor therapeutic radiopharmaceutical 153Sm-TTHMP

JIANG Shu-Bin1, LUO Shun-Zhong1, LIU Guo-Ping1, DENG Hou-Fu2, BING Wen-Zeng1, WANG Wen-Jin1, WEI Hong-Yuan1, HU Shu2   

  1. 1Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics, Mianyang 621900;
    2Department of Nuclear Medicine of First University Hospital, West China Medicine Center, Sichuan University, Chengdu 610041
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JIANG Shu-Bin, LUO Shun-Zhong, LIU Guo-Ping, DENG Hou-Fu, BING Wen-Zeng, WANG Wen-Jin, WEI Hong-Yuan, HU Shu. Preparation and bio-distribution of bone tumor therapeutic radiopharmaceutical 153Sm-TTHMP.Nuclear Science and Techniques, 2003, 14(2): 123

Abstract: Tin is an essential ingredient of most technetium-99m radiopharmaceuticals but its in-vivo distribution and long-term fate are not well understood. This work describes distribution in mice of several tin-117m labeled compounds. The results indicate that stannic-HEDTMP appears to be the best overall bone localizing agent with very low blood, muscle, kidney, or liver uptake, and its binding to bone is higher than that of tin-117m-DTPA, which make it potentially useful as an agent for skeletal scintigraphy and radiotherapy of bone tumors.