Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 1998, Vol. 9 ›› Issue (3): 189

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Preparation and preclinical studies of a hepatic receptor imaging agent

Zhang Rong-Jun, Jin Jian, Liang Gao-Lin, Wan Wei-Xing, Tao Yong-Hui and Wang Bo-Cheng   

  1. State Key Laboratory of Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063
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Zhang Rong-Jun, Jin Jian, Liang Gao-Lin, Wan Wei-Xing, Tao Yong-Hui and Wang Bo-Cheng. Preparation and preclinical studies of a hepatic receptor imaging agent.Nuclear Science and Techniques, 1998, 9(3): 189

Abstract: Galactosyl neoglycoalbumin (NGA) was synthesized by the covalent coupling of a bifunctional reagent, 2-imino-2-ethyloxymethy1-1-thiogalactose, to human serum albumin. The average number of galactose groups per albumin molecule (Gal/HSA) of NGA was 30. NGA was labeled directly with Na99mTcO4. The radiochemical purity of 99mTc-NGA was over 90%. Consequences of the preclinical studies show that 99mTc-NGA is a good hepatic receptor imaging agent, uptaken by hepatic cells specifically, and excreted majorly from the biliary system and the gastrointestinal (GI) tract.

Key words: 99mTc-NGA, Hepatic receptor imaging agent, Bifunctional reagent , Glycoprotein