Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 1998, Vol. 9 ›› Issue (3): 148

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Diagnoses of gastric cancer and other gastric diseases by serum pepsinogen I and II levels

Xiao Zhi-Jian1, Jiang Meng-Jun1, Cheng Zhao-Ming2   

  1. 1 State Key Laboratory of Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063;
    2 Hospital of Zhenjiang Medical College, Zhenjiang 2120001
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Xiao Zhi-Jian, Jiang Meng-Jun, Cheng Zhao-Ming. Diagnoses of gastric cancer and other gastric diseases by serum pepsinogen I and II levels.Nuclear Science and Techniques, 1998, 9(3): 148

Abstract: Serum pepsinogens I and Il (PGI, PGI) levels were determined by PGI and PGILRIA kits in 84 healthy controls and 128 patients of gastric diseases including 42 patients with gastric cancer. The results showed peptic ulcer cases had elevated PGI and PGI levels. The atrophic gastritis cases had low PGI levels and the gastric cancer cases had low PGI and low PGI/PGI ratio. Using the cut-off values of PGI<35μg/L and PGI/PGII<1.5 for clinical purpose, the sensitivity and specificity of the test for gastric cancer was 73% and 78%, respectively. Combined with endoscope examination, the serum PGI and PG I levels are valuable:for: theearly diagnosis of-eastric cancer.

Key words: Pepsinogen, Radioimmunoassay, Gastric cancer, Early diagnosis