Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 1997, Vol. 8 ›› Issue (4): 249

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Studies of Al metabolism in animal by accelerator mass spectrometry

Wang Na-Xiu1, Zhou Wei-Nan1, Liu Lian-Fan1, Cheng Xiao-Wu1, Zhu Jin-Hua1, Qiu Hui-Yuan1, Sun Guo-Yan1, He Shi-Yu1, Zhu Han-Min2, Chen Shu-Ying2, Han Rui-Ping2   

  1. 1 Shanghai Institute of Nuclear Rescarch, the Chinese Academy of Sciences, Shanghai 201800;
    2 Shanahai Institute of Senile Medicine , Shunghui 200040
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Wang Na-Xiu, Zhou Wei-Nan, Liu Lian-Fan, Cheng Xiao-Wu, Zhu Jin-Hua, Qiu Hui-Yuan, Sun Guo-Yan, He Shi-Yu, Zhu Han-Min, Chen Shu-Ying, Han Rui-Ping. Studies of Al metabolism in animal by accelerator mass spectrometry.Nuclear Science and Techniques, 1997, 8(4): 249

Abstract: The correlation between Al metabolisın and senile dementia in animal has been studied by AMS (accelerator mass spectrometry). Three groups of laboratory rats were fed with normal food, food with high Al content, and with enriched Ca and Mg together with high Al2 respectively for six to eight months. Mapping test was made to record the degree of wisdom degeneration. Half of the rats were sacrificel and Al contents in various organs were measured by atomic absorption spectroscopy. The rest were injected with 26Al, killed after 5, 10, 15, 25, and 35d and 26Al contents measured by AMS. The distribution of Al as well as the correlation among the accumulation of 26Al2 and the existed Al content and dementia was studied.

Key words: Accelerator mass spectrometry(AMS), 26Al, Senile dementia, Rats