Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 1997, Vol. 8 ›› Issue (1): 62

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Effects of several Chinese crude drugs on 40Ca transmembrane influx in vascular smooth muscles

Chen Heng-Liu, Mo Shang-Wu, Liu Ning, Zhang Shu-Yuan, Jin Jian-Nan, Li Wen-Xue   

  1. Institute of Nuclear Science and Technology, Sichuan Union University, Chengdu 610064
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Chen Heng-Liu, Mo Shang-Wu, Liu Ning, Zhang Shu-Yuan, Jin Jian-Nan, Li Wen-Xue. Effects of several Chinese crude drugs on 40Ca transmembrane influx in vascular smooth muscles.Nuclear Science and Techniques, 1997, 8(1): 62

Abstract: The effects of several Chinese crude drugs including Crocus sativus, Carthamus tinctorius and Ginkgo biloba on Ca2+ transmembrane influx in rat aorta rings were studied. Resting 45Ca uptake was not markedly altered by these drugs, whereas the 2+Ca influxes evoked by norepinephrine (1.2 μmol/L ) and KCl ( 100 mmol/L ) in rat aorta rings were significantly inhibited by Crocus and Carthamus in a concentration-dependent manner, not by Ginkgo. The results indicate that extracellular Ca2+ transmembrane influx through receptor-operated Ca2+ channels and potential-dependent Ca2+ channels can be blocked by Crocus and Carthamus.

Key words: Radionuclide 45Ca, Crocus sativus L, Carthamus tinctorius L, Ginkgo biloba L, Rat aorta, Ca2+ channels