Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 1996, Vol. 7 ›› Issue (3): 180

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Inhibitory effect of low dose irradiation on tumor metastases in tumor bearing in mice

Wei Dao-Yan(魏道严), Jin Ao-Xing(金敖兴), Huang Guo(黄 帼), Wang Si-Ying(汪思应) and Zuo Xiang-Sheng(左祥生)   

  1. Department of Nuclear Medicine, Anhui Medical University, Hefei 2300382
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Wei Dao-Yan(魏道严), Jin Ao-Xing(金敖兴), Huang Guo(黄 帼), Wang Si-Ying(汪思应) and Zuo Xiang-Sheng(左祥生). Inhibitory effect of low dose irradiation on tumor metastases in tumor bearing in mice.Nuclear Science and Techniques, 1996, 7(3): 180

Abstract: By using the models of tumor blood-borne metastasis and spontaneous one, the antitumor metastasis effect of 75mGy X-ray whole body irradiation on tumor bearing mice is investigated. The results demonstrate that irradiation could significantly inhibit B16 melanoma blood borne pulmonary metastases (P <0.05) and Lewis hing carcinoma (LLC) spontaneous pulmonary metastases(P <0.01). The immunofunction test of B16 melanoma bearing mice shows that the NK (P <0.05) and LAK (P < 0.001) cytotoxicities, and ‘responsibility of splenocytes to IL-2 (P < 0.005) for the irradiated group are increased greatly compared with those of control group. These results suggest that the enhancement of immunofunctions is mduced by low dose radiation to raise antitumor metastasis effects .

Key words: Low dose radiation, Metastasis of neoplasm, Mice, X-rays