Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 1996, Vol. 7 ›› Issue (3): 177

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Preparation and biodistribution of 186,188Re-HEDP for bone tumor therapy

Luo Shun-Zhong1 (罗顺忠), Qiao Jian1 (谯 健), Pu Man-Fei1 (浦满飞), Liu Zhong-Lin1 (刘中林), Zhao Peng-Ji1 (赵鹏骥), Fu Yi-Bei1 (傅依备), Deng Hou-Fu1 (邓候富)   

  1. 1 Southwest Institute of Nuclear Physics and Chemistry, Chengdu 610003;
    2 West China University of Medical Science, Chengdu 610041
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Luo Shun-Zhong(罗顺忠), Qiao Jian(谯 健), Pu Man-Fei(浦满飞), Liu Zhong-Lin(刘中林), Zhao Peng-Ji(赵鹏骥), Fu Yi-Bei(傅依备), Deng Hou-Fu(邓候富). Preparation and biodistribution of 186,188Re-HEDP for bone tumor therapy.Nuclear Science and Techniques, 1996, 7(3): 177

Abstract: Radionuclides 186,188Re, suitable for tumor therapy and with high specific activity, are prepared through irradiating natural metallic rhenium, instead of costly enriched target. Complexation of rhenium with HEDP(1-hydroxy ethylidene diphosphonate) is mainly dependent on pH values and the reductant concentrations in the medium, and the yield is not less than 0.95 in pH 2.0-4.0 and Sn(II) concentration of 0.012-0.018 mol/L. The 186,188ReFEDP complex has high stability in vitro and in vivo in the presence of protecting agent, and gives superior biological properties in small animals, similar to those of 153Sm-EDTMP including faster blood clearance, lower soft tissue residue and higher skeletal uptake with the peak of 0.25761ID/g at 1h post injection (overseas report 0.0101ID/g) comparable to that of 153Sm-EDTMP(0.26441D/g) at 3h post injection.

Key words: Rhenium 186,188, Natural metallic rhenium, 186,188Re-HEDP, Biodistribution