Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 1996, Vol. 7 ›› Issue (3): 170

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Pharmacokinetics local model and its application in nuclear medicine

Cao Guo-Xian(曹国宪), Li Wei-Yi(李卫一) and Yu Hui-Xin(俞惠新)   

  1. Jiangsu Institute of Nuclear Medicine, Wuxi 214068
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Cao Guo-Xian(曹国宪), Li Wei-Yi(李卫一) and Yu Hui-Xin(俞惠新). Pharmacokinetics local model and its application in nuclear medicine.Nuclear Science and Techniques, 1996, 7(3): 170

Abstract: The Pharmacokinetics local model for studying kinetic action of pharmaceuticals in the specific part of the body is established on the basis of the compartment model. A series of formulae is deduced, and with them the pharmacokinetic equation and several important parameters can be obtained. The local model successfully expanded the area of pharmacokinetics from the compartment model, which is mainly dealing with kinetic action of pharmaceuticals in blood, to the local model, which can study kinetic action of pharmaceuticals in any organ, tissue or fluid.

Key words: Pharmacokinetics, Mathematical model, Local model, Computer program