Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 1994, Vol. 5 ›› Issue (2): 93

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RADIOIMMUNOTOXICOLOGICAL EFFECT OF ENRICHED URANIUM ON CENTRAL AND PERIPHERAL IMMUNE CELLS AND THE PROTECTIVE ACTION OF IL—1 AND IL—2

Zhu Shoupeng (朱寿彭), Lai Guanhua (赖冠华) and Wang Liuyi (王六一)   

  1. Faculty of Radiological Medicine, Suzhou Medical College, Suzhou 215007, China
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Zhu Shoupeng (朱寿彭), Lai Guanhua (赖冠华) and Wang Liuyi (王六一). RADIOIMMUNOTOXICOLOGICAL EFFECT OF ENRICHED URANIUM ON CENTRAL AND PERIPHERAL IMMUNE CELLS AND THE PROTECTIVE ACTION OF IL—1 AND IL—2.Nuclear Science and Techniques, 1994, 5(2): 93

Abstract: Accumulation of enriched 235U-UO2F2 in the body had injurious effects on the immune function of central and peripheral immune cells. After an intravenous injection of 235U-UO2F2, the spontaneous H-TdR incorporation in thymocytes and bone marrow cells decreased, with the thymocytes damaged more markedly. The proliferation ability of spleen T and B lymphocytes were both inhibited, with B lymphocytes inhibited more severely. In spleen B lymphocytes the IL-1 production and IL-2 consumption were diminished. The inhibition of spleen B lymphocyte proliferation by 235U-UO2F2 was partially restored by adding exogenous IL-1 or IL-2 to the cultured lymphocytes obtained from 235U injected mice.

Key words: Enriched uranium, Radioimmunotoxicological effect, Interleukin-1, Interleukin- 2, Immune cells, Protective action