Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 1992, Vol. 3 ›› Issue (2): 73

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THE EFFECT OF SOME MEDICAL TREATMENTS ON THE RED BLOOD CELLS IN THE PATIENTS WITH THALASSEMIA

Zhang Xiufang (张秀芳) Shen Linming (沈林明), Bao Hongxia (包红需), Ding Xiaolan (丁晓岚), Wang Rongxin (王容新)靖,Liu Yuanyuan (刘源源), Gao Naifei (高妃飞) and Huang Youwen (黄有文)   

  1. Tsinghua University, Beijing 100084, China
    * 303 Hospital of PLA, Nanning 530021, China
Zhang Xiufang (张秀芳) Shen Linming (沈林明), Bao Hongxia (包红需), Ding Xiaolan (丁晓岚), Wang Rongxin (王容新)靖, Liu Yuanyuan (刘源源), Gao Naifei (高妃飞) and Huang Youwen (黄有文). THE EFFECT OF SOME MEDICAL TREATMENTS ON THE RED BLOOD CELLS IN THE PATIENTS WITH THALASSEMIA.Nuclear Science and Techniques, 1992, 3(2): 73

Abstract: The Mossbauer spectroscopy and circular dichroism measurements have been used to investigate the effect of some medical treatments on the red blood cells (RBCs) of the patients with HbH disease and β -thalassemia major, respectively. The results indicate that both splenectomy and treatment with myleran are effective to alleviate the symptoms of anemia for some patients, but both of them are different in the effect on the RBCs of the patients. On the basis of the results, a hypothesis on the course of denaturation in hemoglobin of the patients is proposed.

Key words: β-thalassemia major, Mossbauer spectroscopy, Circular dichroism, HbH