Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 1990, Vol. 1 ›› Issue (3): 161

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A NEW APPROACH TO THE CURVE FITTING OF IN VITRO RADIOASSAYS BASED ON THE MASS ACTION LOW

Xia Zongqin (夏宗勤)   

  1. Shanghai Second Medical University, Shanghai 200025, China
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Xia Zongqin (夏宗勤). A NEW APPROACH TO THE CURVE FITTING OF IN VITRO RADIOASSAYS BASED ON THE MASS ACTION LOW.Nuclear Science and Techniques, 1990, 1(3): 161

Abstract: A new curve fitting method with its mathematical models derived from the mass action law is presented which is applicable to several in vitro radioassays including RIA and RBA. Experiments revealed that the robustness of this method is better than the conventional methods like Woolf plot in RBA and 4— parameter logistic plot in RIA. However, the robustness of this method is only relative: in some cases of RIA and RBA, the bias of the results may still be too large to be acceptable. Further improvement is expected to be studied.

Key words: Vitro radioassays, Curve fitting, Mathematical models, Mass action law