Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2015, Vol. 26 ›› Issue (6): 060304 doi: 10.13538/j.1001-8042/nst.26.060304

• NUCLEAR CHEMISTRY,RADIOCHEMISTRY,RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE • Previous Articles     Next Articles

Dose evaluation of therapeutic radiolabeled bleomycin complexes based on biodistribution data in wild-type rats: Effect of radionuclides in absorbed dose of different organs

Hassan Yousefnia, Samaneh Zolghadri, Amir Reza Jalilian, and Mohammad Ghannadi-Maragheh   

  1. Nuclear Science and Technology Research Institute (NSTRI), Tehran 14395-836, Iran
  • Contact: Samaneh Zolghadri E-mail:szolghadri@aeoi.org.ir
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Hassan Yousefnia, Samaneh Zolghadri, Amir Reza Jalilian, and Mohammad Ghannadi-Maragheh. Dose evaluation of therapeutic radiolabeled bleomycin complexes based on biodistribution data in wild-type rats: Effect of radionuclides in absorbed dose of different organs.Nuclear Science and Techniques, 2015, 26(6): 060304     doi: 10.13538/j.1001-8042/nst.26.060304

Abstract:

Bleomycins (BLMs), as tumor-seeking antibiotics, have been used for over 20 years in treatment of several types of cancers. Several radioisotopes are used in radiolabeling of BLMs for therapeutic and diagnostic purposes. An important points in developing new radiopharmaceuticals, especially therapeutic agents, is the absorbed dose delivered in critical organs. In this work, absorbed dose to organs after injection of 153Sm-, 177Lu- and 166Ho-labeled BLM was investigated by radiation dose assessment resource (RADAR) method based on biodistribution data in wild-type rats. The absorbed dose effect of the radionuclides was evaluated. The maximum absorbed dose for the complexes was observed in the kidneys, liver and lungs. For all the radiolabeled BLMs, bone and red marrow received considerable absorbed dose. Due to the high energy beta particles emitted by 166Ho, higher absorbed dose is observed for 166Ho-BLM in the most organs. The reported data can be useful for the determination of the maximum permissible injected activity of the radiolabeled BLMs in the treatment planning programs.

Key words: 166Ho, 177Lu, 153Sm, Bleomycin, Dosimetry