Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2014, Vol. 25 ›› Issue (S1): S010302 doi: 10.13538/j.1001-8042/nst.25.S010302

• NUCLEAR CHEMISTRY,RADIOCHEMISTRY,RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE • Previous Articles     Next Articles

Calculation of the intake retention fraction and dose coefficients in 99mTc-labelled compound for internal exposure for medical workers

Tae-Eun Kwon,1, y Siwan Noh,1 Sol Jeong,1 and Jai-Ki Lee1   

  1. 1Hanyang University, 222 Wangsimni-ro, Seongdong-gu, Seoul, Republic of Korea
  • Contact: Tae-Eun Kwon E-mail:ktgrace@hanyang.ac.kr
  • Supported by:

    the National Emergency Management Agency of Korea, the
    Ministry of Environment of Korea

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Tae-Eun Kwon, Siwan Noh, Sol Jeong, and Jai-Ki Lee. Calculation of the intake retention fraction and dose coefficients in 99mTc-labelled compound for internal exposure for medical workers.Nuclear Science and Techniques, 2014, 25(S1): S010302     doi: 10.13538/j.1001-8042/nst.25.S010302

Abstract:

For recent decades, a considerable amount of 99mTc has been stimulated for diagnosis radiopharmaceuticals
because of its physical advantages. The increase in the use of 99mTc makes naturally more chances of internal
exposure for not only patients but also medical workers. The patient internal exposure by an intravenous injection
has been assessed relatively well with the reports of International Commission on Radiological Protection
(ICRP) or Medical Internal Radiation Dose(MIRD). However, there are few studies which can support its accurate
assessment for medical worker who treats 99mTc. In spite of the absence of information, the physiological
information of each 99mTc-labelled compound for patient, provided by ICRP, can be used optionally for worker
exposure because the behaviors after uptake to blood are similar for patient and worker. Using the data, in this
study, the data for bioassay were given as the intake whole-body retention and urinary excretion function. We
selected the two most frequently used 99mTc-labelled compounds based on statistical data; 99mTc-phosphonate,
pertechnetate. The data of the Human Alimentary Tract Model (HATM, publication 100) and the revised Human
Respiratory Tract Model (revised HRTM, OIR) were used for compartment models which depict the physiological
behavior in body after intake. In case of 99mTc-phosphonate, we adopted the systemic model for patient
intake described in ICRP publication 53 based on the assumption that the behaviors after uptake to blood are
similar for patient and worker. On the other hand, recent updated systemic model in OIR report could be directly
adopted for pertechnetate. We used Birchall’s algorithm for calculation and developed the module which
could calculate the retention amounts in each compartment at given time by MATLAB. In addition, we fitted the
functions as sum of exponential terms using ORIGIN and the fitting coecients were provided. We also could
calculate the committed dose coecients for each compound using SAF values for photons provided by Cristy
and Eckerman. The results in this study will be useful to estimate the intake and e ective dose for medical field.

Key words: Intake retention function, Urinary excretion function, 99mTc, Bioassay, Revised HRTM, HATM, Medical worker, Occupational intakes