Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2014, Vol. 25 ›› Issue (6): 060302 doi: 10.13538/j.1001-8042/nst.25.060302


Preparation of 188Re-HEDP lyophilized kit for instant bone metastases therapy

YANG Zhi1,ZHU Hua1,LI Nan1,MA Yun-Xia1,ZHANG Yan1   

  1. 1Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education),
    Department of Nuclear Medicine, Peking University Cancer Hospital & Institute, Beijing 100142, China
  • Contact: YANG Zhi
  • Supported by:

    Supported by the National Natural Science Foundation of China(Nos. 81071198, 81172083 and 81371592) and Beijing Natural Science Foundation (No. 7132040)

PDF ShareIt Export Citation
YANG Zhi, ZHU Hua, LI Nan, MA Yun-Xia, ZHANG Yan. Preparation of 188Re-HEDP lyophilized kit for instant bone metastases therapy.Nuclear Science and Techniques, 2014, 25(6): 060302     doi: 10.13538/j.1001-8042/nst.25.060302


Hydroxyethylidene diphosphonate (HEDP) was prepared and labeled with rhenium-188. Its lyophilized kit
was developed for instant preparing of 188Re-HEDP. 188Re-HEDP showed high focile uptake in normal mice
(> 30% ID/g at carrier co-injection) in BABLC/SPF mice. High quality single photon emission computed
tomography (SPECT) image of New Zealand rabbit was obtained at 4 h after intravenous injection of 74MBq
radiotracer. The lyophilized HEDP kit affords the new opportunity for routine clinical application in bone
metastases therapy.

Key words: Rhenium-188, Hydroxyethylidene diphosphonate, Lyophilized kit, Bone tumor therapy