Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2014, Vol. 25 ›› Issue (5): 050302 doi: 10.13538/j.1001-8042/nst.25.050302

• NUCLEAR CHEMISTRY,RADIOCHEMISTRY,RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE • Previous Articles     Next Articles

Biological characteristics of [18F]-THK523 for tau imaging

KONG Yan-Yan,1 SI Zhan,1 ZHANG Zheng-Wei,1 GUAN Yi-Hui,1 CAO Guo-Xian,2 XUE Fang-Ping,1 HUA Feng-Chun,1 WU Ping,1 ZHAO Jun,1 ZHU Jian-Hua,3 LI Cong,3 CHEN Jian,3 QIAN Jun 3   

  1. 1PET Center, Huashan Hospital, Fudan University, Shanghai 200235, China
    2Key Laboratory of Nuclear Medicine, Ministry of Health, Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China
    3Key Laboratory of Smart Drug Delivery, Ministry of Education & PLA, School of Pharmacy, Fudan University, Shanghai 200032, China
  • Contact: GUAN Yi-Hui E-mail:guanyihui@hotmail.com
  • Supported by:

    Supported by National Natural Science Foundation of China (Nos. 81271516 and 81371625), Program of Shanghai Science and Technology Commission (Nos. 13JC1401503 and 14DZ1930402), Shanghai Municipal Health and Family Planning Commission (No. 2013313) and Exchange Programme Foundation of Doctoral Student under the Office for Graduate Medical Education, Fudan University

PDF ShareIt Export Citation
KONG Yan-Yan, SI Zhan, ZHANG Zheng-Wei, GUAN Yi-Hui, CAO Guo-Xian, XUE Fang-Ping, HUA Feng-Chun, WU Ping, ZHAO Jun, ZHU Jian-Hua, LI Cong, CHEN Jian, QIAN Jun . Biological characteristics of [18F]-THK523 for tau imaging.Nuclear Science and Techniques, 2014, 25(5): 050302     doi: 10.13538/j.1001-8042/nst.25.050302

Abstract:

Reliable and non-invasive diagnostic tools are highly valuable for successful therapeutic strategies for the treatment of Alzheimer’s disease (AD). The existence of neurofibrillary tangles (NFTs) consisting of tau protein are one kind of the pathological features of AD, and its level of severity is correlated with the stage of AD. However, no clinically approved positron emission tomography (PET) probe is currently available for selective imaging of neurofibrillary tangles on patients. In this paper, we report our studies on biological characteristics of [18F]-THK523 as a novel tau imaging probe. With low molecular weight, [18F]-THK523 is stable, electrically neutral, lipophilic and non-mass concentration-dependent. Preliminary biological studies have shown the excellent properties of [18F]-THK523 as brain imaging tracer for further research.

Key words: [18F]-THK523, Neurofibrillary tangles (NFTs), Alzheimer’s disease (AD), Tau-specific probe, Biological characteristics