Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2014, Vol. 25 ›› Issue (4): 040503 doi: 10.13538/j.1001-8042/nst.25.040503 arXiv: ZHANG Feng

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A facile method to build a proton nanosensor with neutral to basic pH sensitive range

ZHONG Rui-Bo, LIU Yu-Shuang, ZHANG Ping, ZHAO Guo-Fen, ZHANG Feng   

  1. 1School of Life Sciences, Inner Mongolia Agricultural University, 306 Zhaowuda Road, Hohhot 010018, China
  • Contact: ZHANG Feng E-mail:fengzhang1978@hotmail.com
  • About author:ZHANG Feng
  • Supported by:

    Supported by grants from the National Natural Science Foundation of China (Nos. 21171086 and 81160213), and Inner Mongolia Grassland Talent (No. 108-108038), and Inner Mongolia Autonomous Region Natural Science Foundation (No. 2013MS1121) and the Inner Mongolia Agricultural University (Nos. 211-109003 and 211-206038)

ZHONG Rui-Bo, LIU Yu-Shuang, ZHANG Ping, ZHAO Guo-Fen, ZHANG Feng . A facile method to build a proton nanosensor with neutral to basic pH sensitive range.Nuclear Science and Techniques, 2014, 25(4): 040503     doi: 10.13538/j.1001-8042/nst.25.040503

Abstract:

Bio-nanosensors (Bio-NSs) have attracted much attention recently due to their unique properties. Among all of the bio-NSs, the intracellular proton sensor is significant for biomedicine studies and clinic diagnosis. Proton nanosensors (PNSs) with different pH sensitive ranges could satisfy different research requirements. Here we report a facile method to build a PNS with a neutral to basic pH sensitive range, in which the commercial pH indicator, fluoresceinamine (FA), was covalently coupled to the carboxylic-rich amphiphilic polymer (AP) coated gold nanoparticles (AuNPs).

Key words: Fluoresceinamine, Proton nanosensor, Fluorescence, Spectrometer, Amphiphilic polymer