Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2011, Vol. 22 ›› Issue (2): 99-104 doi: 10.13538/j.1001-8042/nst.22.99-104

• RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICIN • Previous Articles     Next Articles

Nanographene oxide labeling with (188)Re

ZHANG Xiaoyong1,2 LI Jing1,2 ZHU Ying1 QI Yujin1 ZHU Zhiyong1 LI Wenxin1,HUANG Qing1,   

  1. 1Laboratory of Physical Biology,Shanghai Institute of Applied Physics,Chinese Academy of Sciences,Shanghai 201800,China 2Graduate School of Chinese Academy of Sciences,Beijing 100049,China
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ZHANG Xiaoyong, LI Jing, ZHU Ying, QI Yujin, ZHU Zhiyong, LI Wenxin, HUANG Qing, . Nanographene oxide labeling with (188)Re.Nuclear Science and Techniques, 2011, 22(2): 99-104     doi: 10.13538/j.1001-8042/nst.22.99-104

Abstract:

Nanographene oxide (NGO) is currently being explored for various biomedical applications.However,little information is known about its biological behaviors in vitro and in vivo.For further studying its pharmacokinetics and related biological behaviors in living systems,an effective and convenient tracing method is particularly demanded.In this work,NGO was labeled with radionuclide 188Re (188Re-NGO).To obtain high labeling yield and purity,a number of labeling conditions,including concentration of SnCl2 and ascorbic acid,reaction time and temperature,and pH were optimized,and stability of the 188Re-NGO in vitro and in vivo was evaluated.The results showed that NGO could be effectively labeled with high yield.The purified 188Re-NGO showed high stability in vitro and in vivo.A pretest of NGO biodistribution with single photon emission computed tomography showed that the 188Re-NGO was rapidly taken by organs such as lungs,liver,and spleen.The biodistribution of 188Re-NGO differs significantly from the free radionuclide,indicating that the labeling procedure is highly suitable for investigating its biological behavior in living systems.

Key words: Graphene oxide, Radio-labeling, 188Re, SPECT images, Biodistribution