Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2011, Vol. 22 ›› Issue (6): 344-348 doi: 10.13538/j.1001-8042/nst.22.344-348

• RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICIN • Previous Articles     Next Articles

A high-resolution small animal SPECT system developed at Tsinghua

DAI Tiantian MATianyu~* LIU Hui CUI Junjian WEI Qingyang LIU Yaqiang WANG Shi   

  1. Key Laboratory of Particle & Radiation Imaging,Ministry of Education;Department of Engineering Physics,Tsinghua University,Beijing 10084,China
DAI Tiantian, MATianyu, LIU Hui, CUI Junjian, WEI Qingyang, LIU Yaqiang, WANG Shi . A high-resolution small animal SPECT system developed at Tsinghua.Nuclear Science and Techniques, 2011, 22(6): 344-348     doi: 10.13538/j.1001-8042/nst.22.344-348

Abstract:

An SPECT system dedicated to small animal imaging shall be of a millimeter spatial resolution or even better.This study was aimed at achieving 0.5-mm spatial resolution for a small animal SPECT system at low cost.It was developed from a single-head clinical SPECT scanner,with a seven-pinhole collimator and a four-degree-offreedom motion control stage.Several key techniques were developed,including high-resolution image reconstruction algorithm,high accuracy geometrical calibration method,and optimized system matrix derivation scheme.The system matrix was derived from Monte-Carlo simulation and de-noised by fitting each point spread function to a two dimensional Gaussian function.Experiments of point source and ultra micro hot rod phantom were conducted.With a spatial resolution of 0.5-0.6 mm,this system provides a practical way for low-cost high-resolution animal imaging on a clinic SPECT system.

Key words: SPECT, Multi-pinhole collimator, High resolution, System matrix, Image reconstruction