Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2011, Vol. 22 ›› Issue (3): 174-177 doi: 10.13538/j.1001-8042/nst.22.174-177

• RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICIN • Previous Articles     Next Articles

Study on the reaction kinetics of 99Tcm-labeled BIDP

LIN Jianguo WANG Yan LUO Shineng~* QIU Ling ZHAI Haozhen   

  1. Key Laboratory of Nuclear Medicine,Ministry of Health,Jiangsu Key Laboratory of Molecular Nuclear Medicine,Jiangsu Institute of Nuclear Medicine, Wuxi 214063,China
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LIN Jianguo, WANG Yan, LUO Shineng, QIU Ling, ZHAI Haozhen . Study on the reaction kinetics of 99Tcm-labeled BIDP.Nuclear Science and Techniques, 2011, 22(3): 174-177     doi: 10.13538/j.1001-8042/nst.22.174-177

Abstract:

A novel zoledronic acid derivative,1-hydroxy-2-(2-butyl-1H-imidazole-1-yl)-ethylidene-l,l- diphosphonic acid(BIDP),was synthesized and labeled with ~(99)Tc~m.The detailed kinetic study on the labeling reaction between BIDP and ~(99)Tc~m was carried out.The results indicated that the reaction rate constants k were 0.0258,0.0268, 0.0305,0.0323,0.0351 and 0.0384 min~(-1)at 0℃,5℃,10℃,15℃,20℃and 25℃,respectively.From the Arrhenius equation k=A·e~(-E_Δ/(RT)),the activation energy E_a of the labeling reaction was calculated to be 10.45 kJ/mol.And the correlation between k and temperature(T)was also deduced as In k=-1258.8×(l/T)+0.9531.In addition,it was found that in order to get a high radiolabeling yield(RLY)(>90%),the reaction temperature must be up to 12℃.

Key words: ~(99)Tc~m-BIDP, Labeling reaction kinetics, Reaction rate constant k, Reaction activation energy E, Radiolabeling yield(RLY)