Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2010, Vol. 21 ›› Issue (5): 306-311 doi: 10.13538/j.1001-8042/nst.21.306-311

• RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICIN • Previous Articles     Next Articles

Dual time point FDG PET imaging in evaluating pulmonary nodules with low FDG avidity

CHEN Xiang ZHAO Jinhua* SONG Jianhua XING Yan WANG Taisong QIAO Wenli   

  1. Department of Nuclear Medicine, Shanghai First People's Hospital, Shanghai Jiaotong University, Shanghai, China
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CHEN Xiang, ZHAO Jinhua, SONG Jianhua, XING Yan. Dual time point FDG PET imaging in evaluating pulmonary nodules with low FDG avidity.Nuclear Science and Techniques, 2010, 21(5): 306-311     doi: 10.13538/j.1001-8042/nst.21.306-311

Abstract:

A standardized uptake value(SUV) of 2.5 is frequently used as criteria to evaluate pulmonary lesions. However, false results may occur. Some studies have shown the usefulness of delayed PET for improving accuracy, while others recently have shown fewer promising results. This study was designed to investigate the accuracy of dual time point (DTP) FDG PET imaging in the evaluation of pulmonary lesions with an initial SUV less than 2.5. DTP FDG PET studies were conducted about 1 and 2 hours after FDG injection, and pulmonary lesions with an initial SUV less than 2.5 were identified. Nodules with pathologic results or imaging follow up were included. The differences in SUV and retention index (RI) between benign and malignant pulmonary lesions were analyzed. Receiver operating characteristics (ROC) analysis was performed to evaluate the discriminating validity of SUV and RI. 51 lesions were finally included. A RI greater than 0% was observed in 64% of the benign lesions; 56% had a RI greater than 10%. Among the malignancies, 80.8% had a RI greater than 0%, and 61.5% had a RI greater than 10%. We found no significant differences in SUV and RI between benign and malignant lesions. The area under the ROC curve did not differ from 0.5 whether using SUV or the retention index. Utilizing a SUV increase of 10%, the sensitivity was 61.5%, specificity 44% and accuracy was 52.9%. Dual time point FDG PET may not be of benefit in the evaluation of pulmonary nodules with low FDG avidity.

Key words: Dual time point, Delayed imaging, FDG, Positron emission tomography, Lung nodules