Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2010, Vol. 21 ›› Issue (1): 24-28 doi: 10.13538/j.1001-8042/nst.21.24-28

• RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICIN • Previous Articles     Next Articles

Complement of 99mTc-octreotide scintimammography to mammography in evaluating breast cancers

SU Xinhui1 HE Xiaojiang1 WU Hua1 PAN Weiming1 HUANG Jingxiong1 YU Hao1 CHEN Guibing1 WANG Wei2,*   

  1. 1Department of Nuclear Medicine, No.1Hospital of Xiamen Affiliated to Fujian Medical University, Xiamen 361003, China. 2Department of Anatomy, Histology and Embryology, School of Basic Medical Sciences, Fujian Medical University, Fuzhou 350004, China.
SU Xinhui HE Xiaojiang, WU Hua, PAN Weiming, HUANG Jingxiong, YU Hao, CHEN Guibing, WANG Wei. Complement of 99mTc-octreotide scintimammography to mammography in evaluating breast cancers.Nuclear Science and Techniques, 2010, 21(1): 24-28     doi: 10.13538/j.1001-8042/nst.21.24-28

Abstract:

In this paper, the 99mTc-octreotide scintimammography as a useful complementary technique of mammography was evaluated in diagnosing breast cancers. The 45 breast lesions were consecutively detected by mammography, and 99mTc-octreotide scintimammography, and both combination technique on the basis of self-examination, physical examination. Clinical diagnosis was confirmed by histopathologic analysis. Radioactivity uptake ratios for tumor vs normal breast tissues (T/NT) were calculated using regions of interest. In the breast cancer groups and the benign lesion groups, the average uptake ratios of the 99mTc-octreotide were 1.63±0.19 and 1.09±0.13, respectively, and t was 9.638 (P<0.001). Based on sensitivity, specificity, accuracy, positive predicting value, and negative predicting value, 99mTc-octreotide scintimammography was 87%, 79%, 84%, 90%, and 73%, the mammography was 65%, 64%, 64%, 80%, and 45%, and both combination was 95%, 100%, 97%, 100% and 92%, respectively. This showed that the 99mTc-octreotide scintimammography was more useful than mammography in the evaluating suspected breast cancers, and the combination technique can accurately discriminate lesions.

Key words: Breast cancer diagnosis, 99mTc-octreotide scintimammograpy, Mammography