Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2010, Vol. 21 ›› Issue (4): 209-213 doi: 10.13538/j.1001-8042/nst.21.209-213

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Differentiation of illicit drugs with THz time-domain spectroscopy

LIU Guifeng MA Shihua JI Te ZHAO Hongwei WANG Wenfeng*   

  1. Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Shanghai 201800, China
LIU Guifeng, MA Shihua, JI Te, ZHAO Hongwei, WANG Wenfeng. Differentiation of illicit drugs with THz time-domain spectroscopy.Nuclear Science and Techniques, 2010, 21(4): 209-213     doi: 10.13538/j.1001-8042/nst.21.209-213

Abstract:

The terahertz time-domain spectroscopy (THz-TDS) was used for sensing and identifying illicit drugs. The absorption spectra of seven illicit drug samples (morphine and its hydrochloride, cocaine hydrochloride, codeine phosphate, papaverine hydrochloride, pethidine hydrochloride, and thebaine) were studied by THz-TDS at 0.3–2.0 THz at room temperature. The geometric structure and vibration frequencies of morphine were calculated by density functional theory. The four absorption features were dominated by intra-/inter-molecular collective or lattice vibration modes. Each illicit drug has a distinct signature in its THz spectra. The results indicate that the THz-TDS can be used to identify and discriminate illicit drugs by their characteristic fingerprints.

Key words: Terahertz, THz-TDS, Illicit drugs, DFT, Morphine