Development of 153Sm-bleomycin as a possible therapeutic complex

doi:10.13538/j.1001-8042/nst.21.165-170

Abstract

Abstract:

Due to interesting therapeutic properties of 153Sm and antineoplastic antibiotic, bleomycin (BLM), 153Sm-bleomycin (153Sm-BLM) was developed as a possible therapeutic compound using 153SmCl3 and BLM. The 153SmCl3 was obtained by thermal neutron flux (5×1013 n·cm–2·s–1) of an enriched 152Sm2O3 sample, dissolved in acidic media. Under optimized conditions (room temperature, 45 min, 0.1 mg bleomycin for 740–3700 MBq 153SmCl3) a radiochemical purity over 98 % was obtained shown by HPLC (Specific activity = 55 TBq/mM). The 153SmCl3 and 153Sm-BLM were administered into wild-type rats up to 96 h followed by biodistribution. The SPECT imaging of labeled compound in wild-type rats was performed and significant image pattern was observed for a radiolabeled bleomycin compound. The 153Sm-BLM is a potential therapeutic compound and our experiments on this compound have shown satisfactory quality, and stability suitable for future therapeutic studies.

Key words: Bleomycin, Sm-153, Biodistribution, Radiolabeling

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Nuclear Science and Techniques

Development of 153Sm-bleomycin as a possible therapeutic complex

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