Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2010, Vol. 21 ›› Issue (2): 106-109 doi: 10.13538/j.1001-8042/nst.21.106-109

• RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICIN • Previous Articles     Next Articles

Preparation and preliminary biological evaluation of 99mTc-ANMdU

LU Chunxiong1,2,* JIANG Quanfu2 YU Huixin1,2 WANG Songpei2 Li Xiaomin2 WANG Zhengwu1,3,*   

  1. 1School of Chemical & Material Engineering, Jiangnan University,Wuxi 214122, China 2Key Laboratory of Nuclear Medicine, Ministry of Health/Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China 3Department of Food Science ? Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China
PDF ShareIt Export Citation
LU Chunxiong, JIANG Quanfu, YU Huixin, WANG Songpei, Li Xiaomin, WANG Zhengwu. Preparation and preliminary biological evaluation of 99mTc-ANMdU.Nuclear Science and Techniques, 2010, 21(2): 106-109     doi: 10.13538/j.1001-8042/nst.21.106-109

Abstract:

Technetium-99m-labeled-5-{2-sulfanylethyl-[2-(2-sulfanylethylamino)acetyl]amino}-methyl-2′-deoxy- uridine (99mTc-ANMdU) was reported. The precursor ANMdU was synthesized by six-step reactions and all intermediates were verified with MS and 1HNMR. Using SnCl2 as reducing agent, a labeling reaction was carried out at 100°C for 30 min. The radiochemical purity of the 99mTc-ANMdU was 96.68%. Partition coefficients were 0.92 and 0.70 at pH 7.0 and 7.4 of the phosphate buffer saline, respectively. Biodistribution of 99mTc-ANMdU in normal mice showed that the initial uptake of 99mTc-ANMdU in vivo and the clearance was rapid.

Key words: Synthesis, 99mTc-ANMdU, Biodistribution, A thymidine analog