Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2010, Vol. 21 ›› Issue (2): 106-109 doi: 10.13538/j.1001-8042/nst.21.106-109


Preparation and preliminary biological evaluation of 99mTc-ANMdU

LU Chunxiong1,2,* JIANG Quanfu2 YU Huixin1,2 WANG Songpei2 Li Xiaomin2 WANG Zhengwu1,3,*   

  1. 1School of Chemical & Material Engineering, Jiangnan University,Wuxi 214122, China 2Key Laboratory of Nuclear Medicine, Ministry of Health/Jiangsu Key Laboratory of Molecular Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063, China 3Department of Food Science ? Technology, School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai 200240, China
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LU Chunxiong, JIANG Quanfu, YU Huixin, WANG Songpei, Li Xiaomin, WANG Zhengwu. Preparation and preliminary biological evaluation of 99mTc-ANMdU.Nuclear Science and Techniques, 2010, 21(2): 106-109     doi: 10.13538/j.1001-8042/nst.21.106-109


Technetium-99m-labeled-5-{2-sulfanylethyl-[2-(2-sulfanylethylamino)acetyl]amino}-methyl-2′-deoxy- uridine (99mTc-ANMdU) was reported. The precursor ANMdU was synthesized by six-step reactions and all intermediates were verified with MS and 1HNMR. Using SnCl2 as reducing agent, a labeling reaction was carried out at 100°C for 30 min. The radiochemical purity of the 99mTc-ANMdU was 96.68%. Partition coefficients were 0.92 and 0.70 at pH 7.0 and 7.4 of the phosphate buffer saline, respectively. Biodistribution of 99mTc-ANMdU in normal mice showed that the initial uptake of 99mTc-ANMdU in vivo and the clearance was rapid.

Key words: Synthesis, 99mTc-ANMdU, Biodistribution, A thymidine analog