Risk of simulated microgravity on testicular injury induced by high-LET carbon-ion beams in mice

doi:10.13538/j.1001-8042/nst.2013.06.002

Nuclear Science and Techniques ›› 2013, Vol. 24 ›› Issue (6): 060303 doi: 10.13538/j.1001-8042/nst.2013.06.002

• NUCLEAR CHEMISTRY,RADIOCHEMISTRY,RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE • Previous Articles Next Articles

Risk of simulated microgravity on testicular injury induced by high-LET carbon-ion beams in mice

LIU Yang ^1,2,3 ZHANG Luwei ^1,2,3 ZHANG Hong ^1,2,3,*WU Zhenhua ^1,2,3#br# Wang Zhenhua ^1,2,3 WANG Yibo ⁴ LI Hongyan ^1,2,3 MA Xiaofei ^1,2,3 XIE Yi^1,2,3

¹Department of Heavy Ion Radiation Medicine, Institute of Modern physics, Chinese Academy of Sciences, Lanzhou 730000, China
²Key Laboratory of Heavy Ion Radiation Biology and Medicine of Chinese Academy of Sciences, Lanzhou 730000, China
³Key Laboratory of Heavy Ion Radiation Medicine of Gansu Province, Lanzhou 730000, China
⁴College of Life Science and chemistry, Tianshui Normal University, Tianshui 741000, China

Contact: ZHANG Hong E-mail:zhangh@ impcas. ac.cn
Supported by:
Supported by grants from the National Basic Research Program of China (No.2010CB834202), Knowledge Innovation Projection of Chinese Academy of Science (No.KJCX2-YW-L08), The National Natural Science Foundation of China (No.10835011, No.10675151, No.41161058, No.31060065 and No.10805064)

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LIU Yang, ZHANG Luwei, ZHANG Hong, WU Zhenhua. Risk of simulated microgravity on testicular injury induced by high-LET carbon-ion beams in mice.Nuclear Science and Techniques, 2013, 24(6): 060303 doi: 10.13538/j.1001-8042/nst.2013.06.002

Abstract

Abstract:

This study investigated the impact of simulated microgravity on acute injury induced by low doses of carbon ions in male reproductive organs of mice, and determined alterations in spermatogenic function and expression levels of apoptotic factors in mice following exposure to acute irradiation after 7 days of simulated microgravity. The results demonstrated that significant reductions in spermatozoa, primary spermatocytes and spermatogonia, and increased globular cells in seminiferous tubule and pro-apoptotic proteins were observed in the group exposed to over 0.4 Gy irradiation. Collectively, the data suggest that lesions inflicted by simulated microgravity are not markedly modified by lower doses of irradiation (0.2 Gy) in mouse testis compared to the control group. However, testicular impairments were markedly evident in the group exposed to higher doses of carbon ions plus simulated microgravity, which may be due at least in part to elevated apoptosis initiated by the mitochondrial apoptosis pathway in germ cells.

Key words: Stimulated microgravity, High-LET irradiation, Carbon ion, Mouse testis

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Nuclear Science and Techniques

Risk of simulated microgravity on testicular injury induced by high-LET carbon-ion beams in mice

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