Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2013, Vol. 24 ›› Issue (2): 020301 doi: 10.13538/j.1001-8042/nst.2013.02.009

• NUCLEAR CHEMISTRY,RADIOCHEMISTRY,RADIOPHARMACEUTICALS AND NUCLEAR MEDICINE • Previous Articles     Next Articles

A pilot study on 99mTc-3PRGD2 scintigraphy in diagnosis of brain glioma

GAO Shi1  MA Qingjie1  CUI QuLIU Lin1  ZHOU Xueyan1  JIA Bing2
CHEN Zuowei3  ZHANG Haishan1,*     

  1. 1China-Japan Union Hospital, Jilin University, Changchun 130033, China
    2Medical Isotopes Research Center, Peking University, Beijing 100191, China
    3Department of Nuclear Medicine, People’s Hospital of Shenzhen, Shenzhen 518020, China
  • Received:2012-06-30
  • Contact: ZHANG Haishan? E-mail: zhanghaishanmd@yahoo.com.cn
  • Supported by:

    Supported by the National Natural Science Foundation of China projects (No.81271606) and the Research Fund of Science and Technology Department of Jilin province (No.200705327, No.201015185, and No.201201041) and the Research Fund of Shenzhen Sci-tech Department of Guangdong province (No.201102154)

GAO Shi, MA Qingjie, CUI Qu, LIU Lin, ZHOU Xueyan, JIA Bing, CHEN Zuowei, ZHANG Haishan?. A pilot study on 99mTc-3PRGD2 scintigraphy in diagnosis of brain glioma.Nuclear Science and Techniques, 2013, 24(2): 020301     doi: 10.13538/j.1001-8042/nst.2013.02.009
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Abstract:

The 99mTc-3PRGD2 targeted SPECT/CT scanning was of significance in detecting differentiated glioma. In this work, the diagnostic value of 99mTc-3PRGD2 scintigraphy in brain glioma was evaluated by the ten clinically verified brain glioma patients after obtaining informed consent. The patients first accepted X-ray imaging to localize the detecting regions before administrating with 99mTc-3PRGD2 at a mean radioactivity of 849±115 MBq via single intravenous bolus injection 2 h prior to SPECT/CT imaging. Tumor samples for detecting αvβ3 were collected by surgical operations two weeks after the scintigraphy. The results of CT and SPECT scanning were merged and compared. The correlation between tumor occupation (T/N ratio) and αvβ3 expression level were analyzed. The T/N ratios in brain glioma were proportionally correlated to αvβ3 positive cell percentage (R2=0.9253, p<0.05). This study primarily evaluated the clinical application of 99mTc-3PRGD2 SPECT scintigraphy on brain glioma. The more pathological types and detecting strategies covering a large amount of samples would aid to clarify the potentials.

Key words: Radioactive tracer , Tumor , SPECT , CT , Integrin