Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2013, Vol. 24 ›› Issue (1): 010101 doi: 10.13538/j.1001-8042/nst.2013.01.006


Potential applications of synchrotron radiation to the treatment of cancer

SHI Zeliang, ZHOU Shuhui, FU Shen   

  1. 1Department of Radiation Oncology, Shanghai No.6 People’s Hospital Affiliated to Shanghai Jiaotong University, Shanghai 200233, China
    2Medical College of Soochow University Radiology and Protection Institute, Suzhou 215123, China
  • Received:2012-11-27
  • Supported by:

    Supported by Shanghai Jiaotong University and Science and Technology Commission of Shanghai, China (Nos. YG2012ZD02 and 12JC1407400);National Natural Science Foundation of China (Nos.81272506 and 61227017)

SHI Zeliang, ZHOU Shuhui, FU Shen. Potential applications of synchrotron radiation to the treatment of cancer.Nuclear Science and Techniques, 2013, 24(1): 010101     doi: 10.13538/j.1001-8042/nst.2013.01.006


Although conventional radiotherapy remains to be one of the most useful treatments for cancer, it is not the best strategy to maximize the effects on the tumors and minimize the damage to the surrounding tissues due to its physical and biological characteristics. Synchrotron radiation (SR) with uniquely physical and biological advantages may represent an innovative approach for cancer treatment. In recent years, SR-based photon activation therapy, stereotactic synchrotron radiation therapy and micro-beam radiation treatment have been developed, and the results of in vitro and in vivo experiments are very promising. It is necessary to understand the physical and radiobiological principle of those novel strategies before the approach is applied to the clinic. In this paper, we summarize the advances of SR in terms of physical, radiobiological advantages and its potential clinical applications. With the successful operation of shanghai synchrotron radiation, good opportunities in China have been provided for investigations on the treatment of cancer with synchrotron radiation.

Key words: Synchrotron radiation, Photon activation therapy, Stereotactic synchrotron radiation therapy, Microbeam radiation therapy