Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2013, Vol. 24 ›› Issue (1): 010201 doi: 10.13538/j.1001-8042/nst.2013.01.005

• LOW ENERGY ACCELERATOR, RAY AND APPLICATIONS • Previous Articles     Next Articles

Terahertz identification and quantification of penicillamine enantiomers

 JI Te, ZHAO Hongwei, HAN Pengyu, CHEN Min, XIAO Tiqiao   

  1. 1Shanghai Institute of Applied Physics, Chinese Academy of Sciences, Jiading Campus, Shanghai 201800, China
    2Center for Terahertz Research, Rensselaer Polytechnic Institute, 110 8 th Street, Troy, NY 12180, USA
  • Received:2012-12-05
  • Supported by:

    Supported by National Natural Science Foundation of China (No.60907044);the Major State Basic Research Development Program in China (No.2010CB834301);Chinese Academy of Sciences Key Project of International Co-operation (No.GJHZ09058);Science Foundation of the Chinese Academy of Sciences

JI Te, ZHAO Hongwei, HAN Pengyu, CHEN Min, XIAO Tiqiao. Terahertz identification and quantification of penicillamine enantiomers.Nuclear Science and Techniques, 2013, 24(1): 010201     doi: 10.13538/j.1001-8042/nst.2013.01.005


Identification and characterization of L-, D- and DL- penicillamine were demonstrated by Terahertz time-domain spectroscopy (THz-TDS). To understand the physical origins of the low frequency resonant modes, the density functional theory (DFT) was adopted for theoretical calculation. It was found that the collective THz frequency motions were decided by the intramolecular and intermolecular hydrogen bond interactions. Moreover, the quantification of penicillamine enantiomers mixture was demonstrated by a THz spectra fitting method with a relative error of less than 3.5%. This technique can be a valuable tool for the discrimination and quantification of chiral drugs in pharmaceutical industry.

Key words: Terahertz spectroscopy, Vibration modes, Quantitative analysis