Preparation and biodistribution of 99Tcm-PIDP as bone imaging agent

doi:10.13538/j.1001-8042/nst.20.302-306

Abstract

Abstract:

A novel zoledronic acid derivative, 1-hydroxy-2-(2-propyl-1H-imidazol-1-yl)ethane-1,1-diyldiphosphonic acid (PIDP), was synthesized by three-step reactions from 2-propyl-1H-imidazole. It was labeled with 99Tcm in conditions of 0.1 mg SnCl2·2H2O at pH 6.0 and 99TcmO4 ? in aqueous solution for 20 min at room temperature. The labeling yield and radiochemical purity of 99Tcm-PIDP are both higher than 95%. The biodistribution results show that the bone uptake is up to 8.47%ID/g which is the maximum of bone uptake at 30 min after injection of 99Tcm-PIDP in mice. The pharmacokinetic parameters can be estimated from the exponential equation of C=59.565e-11.307t + 2.069e-1.211t. The clear bone image of rabbit was obtained at 120 min after injection of 99Tcm-PIDP. The results indicate that 99Tcm-PIDP has highly selective uptake in the skeletal and low uptake, rapid clearance in soft tissues, so it would be a potential novel bone imaging agent.

Key words: Diphosphonic acid, Bone imaging agent, 99Tcm-PIDP, Biodistribution

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Preparation and biodistribution of 99Tcm-PIDP as bone imaging agent

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