Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2009, Vol. 20 ›› Issue (4): 235-242 doi: 10.13538/j.1001-8042/nst.20.235-242


Metabolic assessement of spleen infiltration by non-Hodgkin lymphoma using 18F-FDG PET/CT: Preliminary clinical results

SUN Long PAN Weimin LUO Zuoming WEI Jihong ZHAO Long WU Hua*   

  1. Minnan PET Center and Department of Nuclear Medicine, No.1 Hospital of Xiamen, Fujian Medical University, Xiamen 316003, China
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SUN Long, PAN Weimin, LUO Zuoming, WEI Jihong, ZHAO Long, WU Hua. Metabolic assessement of spleen infiltration by non-Hodgkin lymphoma using 18F-FDG PET/CT: Preliminary clinical results.Nuclear Science and Techniques, 2009, 20(4): 235-242     doi: 10.13538/j.1001-8042/nst.20.235-242


18F-FDG PET/CT was used for evaluation of spleen infiltration in patients with B-cell non-Hodgkin lymphoma (NHL). Five patients with histological diagnosed B-cell NHL underwent 18F-FDG PET/CT examination. On integrated PET/CT image, spleen infiltration was considered when PET images revealed a discrete margin of solid splenic masses or diffuse lesion of spleen with higher maximum standardized uptake value (SUV) greater than those of normal liver structures. CT images demonstrating a positive splenic index (>480 mL) or focal hypodensities were classified as positive for spleen infiltration. All the patients underwent systemic chemotherapy. The 18F-FDG PET and CT results were compared with final diagnoses. All patients had spleen infiltration originating from B-cell NHL at final diagnosis. Final diagnoses, which were confirmed by clinical and CT (n=3) or 18F-FDG PET/CT (n=1) follow-up in 4 patients and biopsy of 1 patient. On integrated PET/CT image, 18F-FDG PET was true-positive in all 5 patients with spleen infiltration. CT was true-positive in 4 of the 5 patients with spleen infiltration and false-negative in 1 patients (spleen infiltration without morphology changes). The accuracies of 18F-FDG PET and CT for evaluating the spleen infiltration were 100% and 80% at staging, respectively. Our preliminary results suggested metabolic imaging of 18F-FDG PET/CT may be helpful in the diagnosis of spleen infiltration in B-cell NHL patients. These patients may benefit from 18F-FDG PET/CT in diagnosis, when spleen infiltration without morphology changes, which may not be diagnosed exactly by conventional image.

Key words: Non-Hodgkin lymphoma, 18F-fluorodeoxyglucose, Positron emission tomography/computed tomography, Splenic lymphoma, Lymphoma staging