Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2008, Vol. 19 ›› Issue (4): 223 doi: 10.1016/S1001-8042(08)60054-8

• RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICIN • Previous Articles     Next Articles

Preparation and primary biological evaluation of novel nitrido-188Re complexes/lipiodol

WANG Guanquan* WEI Hongyuan LUO Shunzhong HE Jiaheng YANG Yuqing WANG Wenjin XIONG Xiaoling   

  1. Institute of Nuclear Physics and Chemistry, China Academy of Engineering Physics (CAEP), Mianyang 621900, China
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WANG Guanquan WEI Hongyuan LUO Shunzhong HE Jiaheng YANG Yuqing WANG Wenjin XIONG Xiaoling. Preparation and primary biological evaluation of novel nitrido-188Re complexes/lipiodol.Nuclear Science and Techniques, 2008, 19(4): 223     doi: 10.1016/S1001-8042(08)60054-8

Abstract: Two new nitrido-188Re complexes were prepared by a modified method in high yield. These complexes were stable in vitro. The biodistribution in normal mice showed that these nitrido-188Re complexes could accumulate in liver and dissipate quickly from almost all organs. TAE was performed with the use of lipiodol solutions of two complexes to rabbit VX2 liver tumor models. SPECT images showed that the two lipiodol solutions could remain in tumor for about 9 h (188ReN-NEPTDD/lipiodol) and 12 h (188ReN-NEMMPTDD/lipiodol), respectively.

Key words: Nitrido, TDD derivatives, Lipiodol, Liver cancer