Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2019 Impact factor 1.556

Nuclear Science and Techniques ›› 2008, Vol. 19 ›› Issue (3): 165 doi: 10.1016/S1001-8042(08)60044-5


Preparation and preliminary biological evaluation of 99Tcm-TADP as bone imaging agent

YAN Xiaohong1,2 LUO Shineng2,1,* NIU Guosai1,2 YE Wanzhong2 YANG Min2 WANG Hongyong2 XIA Yongmei1   

  1. 1School of Chemical and Material Engineering, Southern Yangtze University, Wuxi 214122, China
    2Key Laboratory of Nuclear Medicine (Jiangsu Institute of Nuclear Medicine), Ministry of Health, Wuxi 214063, China
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YAN Xiaohong LUO Shineng NIU Guosai YE Wanzhong YANG Min WANG Hongyong XIA Yongmei . Preparation and preliminary biological evaluation of 99Tcm-TADP as bone imaging agent.Nuclear Science and Techniques, 2008, 19(3): 165     doi: 10.1016/S1001-8042(08)60044-5

Abstract: TADP, 2-(1H-1,2,4-triazol-1-yl)-1-hydroxyethane-1,1-diphosphonic acid, was synthesized by three step reactions from the raw material 1H-1,2,4-triazole. 99Tcm-TADP was prepared with 5 mg TADP at pH 7.0 by joining 99TcmO4-with SnCl2·2H2O in aqueous solution for 10 min at room temperature. Both labeling yield and radiochemical purity of 99Tcm-TADP were more than 95%. The biodistribution in rats and bone scan in rabbits were also studied. The uptake of organ was expressed as %ID/g. The results showed that the bone uptake is up to 17.17%ID/g which is the maximum of bone uptake at 30 min after injection of 99Tcm-TADP in rats, bone-to-muscle and bone-to-blood uptake ratios were 61.32 and 13.21, respectively. The clear bone image of rabbit was obtained at 120 min after injection of 99Tcm-TADP and clearance in soft tissue was visible. The preparation of 99Tcm-TADP was convenient and 99Tcm-TADP exhibited high uptake in bone, and it would be a potential new bone imaging agent.

Key words: Bone-imaging agent, 99Tcm-labeled TADP, Bio-evaluation