Nuclear Science and Techniques

《核技术》(英文版) ISSN 1001-8042 CN 31-1559/TL     2018 Impact factor 0.961

Nuclear Science and Techniques ›› 2008, Vol. 19 ›› Issue (3): 159 doi: 10.1016/S1001-8042(08)60043-3

• RADIOCHEMISTRY, RADIOPHARMACEUTICALS AND NUCLEAR MEDICIN • Previous Articles     Next Articles

Biodistribution study of [61Cu]pyruvaldehyde-bis (N-4-methylthiosemicarbazone) in normal rats as a PET tracer

Amir Reza JALILIAN1* Saeed SHANESAZZADEH2 Pejaman ROWSHANFARZAD1 Fatemeh BOLOURINOVIN1 Abbas MAJDABADI1   

  1. 1Nuclear Medicine Research Group, Agriculture, Medicine and Industrial Research School (AMIRS), Karaj, Iran;
    2Department of Medical Physics, Tehran University of Medical Sciences, Tehran, Iran
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Amir Reza JALILIAN Saeed SHANESAZZADEH Pejaman ROWSHANFARZAD Fatemeh BOLOURINOVIN Abbas MAJDABADI. Biodistribution study of [61Cu]pyruvaldehyde-bis (N-4-methylthiosemicarbazone) in normal rats as a PET tracer.Nuclear Science and Techniques, 2008, 19(3): 159     doi: 10.1016/S1001-8042(08)60043-3

Abstract: [61Cu]-labeled pyruvaldehyde-bis(N-4-methylthiosemicarbazone) (61Cu-PTSM), a promising agent made for imaging blood perfusion, was produced via the natZn(p,x)61Cu nuclear reaction in a 30 MeV cyclotron, and separated by a two-step column chromatography method developed in our laboratory using a cation and an anion exchange resin. After 150 μA irradiation for 76 min, about 6.006 Ci of 61Cu2+ was obtained with a radiochemical separation yield of 95% and a radionuclidic purity of 99%. 61Cu-PTSM was prepared using an optimized method with in-house synthesized PTSM ligand for radiolabeling following quality control procedures using RTLC and HPLC. The tracer is mostly incorporated in heart, kidneys and brain compared to free copper cation as a control. These are in agreement with former reports. In conclusion, [61Cu]-PTSM was prepared at the radiopharmaceutical scales with high quality and is a potential PET tracer in the perfusion study of the heart, kidney, brain and tumors.

Key words: Copper-61, PTSM, Biodistribution, Radiolabeling